The hardest thing about commuting on two wheels is getting the motor started in the morning.
I have two different two-wheel vehicles that I commute with... one with it's own motor, the other uses my legs for the motor. Either way, sometimes the motor doesn't want to start on cold mornings. I may be able to fix that problem on the scooter by getting a new battery. As for the bicycle, I'm fortunate enough to have the time to eat a decent breakfast and have a warm cup of coffee at home before I need to commute. I rarely need to be on campus before 10am, so I can wait until it warms up a bit outside.